Distinct B-cell populations are present in hepatic and intestinal Schistosoma mansoni granulomas
Journal | Volume 62 - 1999 |
Issue | Fasc.2 - Original articles |
Author(s) | W.Jacobs, J. Bogers, E. Van Marck |
Full article |
VIEW FREE PDF |
Department of Pathology, University of Antwerp (U.I.A.), ** Research Assistant of the Fonds voor Wetenschappelijk Onderzoek - Vlaanderen. |
Although it is generally accepted that schistosomal granuloma formation results from a T-cell dependent host response towards the parasite egg, attention has recently been focused on the involvement of B-cells in the induction of schistosome-induced pathology. In this study we investigated the involvement of two functionally different B-cell populations in the formation of the Schislosoma mansoni granuloma : naive and antigen-stimulated B-cells. In liver granulomas two distinct B-cell populations were found, namely unstimulated Bcells at the periphery of the granuloma and antigen-stimulated, syndecan-1 positive B-cells in the inner part near the deposited egg. Intestinal granulomas differed by their relative lack of unstimulated B-cells at the granuloma periphery, but like hepatic granulomas intestinal granulomas also have syndecan-1 positive B-cells. From our results, we conclude that B-celis are important constituents Of the S. mansoni granuloma. |
© Acta Gastro-Enterologica Belgica. |